Respiratory ATP synthesis as drug target for combating tuberculosis
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منابع مشابه
Novel antibiotics targeting respiratory ATP synthesis in Gram-positive pathogenic bacteria.
Emergence of drug-resistant bacteria represents a high, unmet medical need, and discovery of new antibacterials acting on new bacterial targets is strongly needed. ATP synthase has been validated as an antibacterial target in Mycobacterium tuberculosis, where its activity can be specifically blocked by the diarylquinoline TMC207. However, potency of TMC207 is restricted to mycobacteria with lit...
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34 Emergence of drug-resistant bacteria represents a high, unmet medical need and discovery of 35 new antibacterials acting on new bacterial targets is strongly needed. ATP synthase has been 36 validated as antibacterial target in Mycobacterium tuberculosis, where its activity can be 37 specifically blocked by the diarylquinoline TMC207. However, potency of TMC207 is 38 restricted to mycobacter...
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